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Originally published In Press as doi:10.1167/iovs.08-3217 on April 1, 2009
 (Investigative Ophthalmology and Visual Science. 2009;50:3960-3963.)
© 2009 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.08-3217
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Retinal Vessel Diameters in Relation to Hematocrit Variation during Acclimatization of Highlanders to Sea Level Altitude

Peter Kristian Kofoed,1 Birgit Sander,1 Gustavo Zubieta-Calleja,1,2 Line Kessel,1 and Michael Larsen1,3

1From the Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark; the 2High Altitude Pathology Institute, La Paz, Bolivia; and the 3National Eye Clinic, Kennedy Center, Glostrup, Denmark.

PURPOSE. To examine variations in retinal vessel diameters during acclimatization of native highlanders to normobaric normoxia at sea level.

METHODS. Fifteen healthy residents of the greater La Paz region in Bolivia (3600 m above sea level) were examined thrice over a 72-day period, after having traveled by airplane to Copenhagen, Denmark, near sea level.

RESULTS. In the study subjects, hematocrit decreased from 49.6% (day 2) to 45.9% (P = 0.0066, day 23) and 41.7% (P < 0.0001, day 72); from days 2 to 23, retinal vein diameter increased by 2.68% (P = 0.0079); whereas retinal artery and vein diameters were indistinguishable from baseline after 72 days. No funduscopic signs of retinopathy were observed. Arterial blood pressure remained stable throughout the study.

CONCLUSIONS. Although a 16% reduction in hematocrit occurred between days 2 and 72 after arrival at sea level, the only significant excursion observed was that the diameter of the veins was larger at day 23 than at days 2 and 72. Retinal vessel diameters demonstrated a wide homeostatic range during acclimatization-driven hematocrit variation.




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P. K. Kofoed, B. Sander, G. Zubieta-Calleja, L. Kessel, K. Klemp, and M. Larsen
The Effect of High- to Low-Altitude Adaptation on the Multifocal Electroretinogram
Invest. Ophthalmol. Vis. Sci., August 1, 2009; 50(8): 3964 - 3969.
[Abstract] [Full Text] [PDF]


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