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Originally published In Press as doi:10.1167/iovs.08-3260 on April 15, 2009
 (Investigative Ophthalmology and Visual Science. 2009;50:4029-4032.)
© 2009 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.08-3260
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Reduced Retinal Vessel Response to Flicker Stimulation but Not to Exogenous Nitric Oxide in Type 1 Diabetes

Berthold Pemp,1 Gerhard Garhofer,1 Günther Weigert,1 Katharina Karl,1 Hemma Resch,1,2 Michael Wolzt,1 and Leopold Schmetterer1,3

1From the Departments of Clinical Pharmacology and 2Ophthalmology and the 3Center for Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria.

PURPOSE. Various studies have shown that retinal vessels in patients with diabetes mellitus have a reduced capacity to adapt to changes in perfusion pressure and to stimulation with flickering light. Structural and functional changes in retinal vessels in diabetes could lead to a general reduction of vasodilator and/or vasoconstrictor capacity. To gain more insight into this topic, we compared the response of retinal vessel diameters to systemic glyceryl trinitrate (GTN) and stimulation with diffuse luminance flicker in patients with diabetes and healthy control subjects.

METHODS. Twenty patients with type 1 diabetes mellitus featuring no or mild nonproliferative diabetic retinopathy and 20 healthy, age-matched subjects were included in this study. A vessel analyzer was used for measurement of diameters of retinal arteries and veins. The response of diameters was measured continuously during stimulation with flickering light, as well as immediately after sublingual application of 0.8 mg GTN.

RESULTS. The response of retinal vessels to flickering light was significantly reduced in the patients with diabetes (arteries: 2.9% in diabetes versus 7.0% in control subjects, P < 0.002; veins: 4.6% in diabetes versus 6.8% in control subjects, P = 0.020). GTN-induced vasodilatation was not different between the patients with diabetes and the healthy control subjects (P ≥ 0.70).

CONCLUSIONS. The present study confirmed reduced response of retinal vessels to stimulation with flickering light in diabetes. The response of retinal vessels to a direct NO-donor, however, was maintained. This result indicates that abnormal flicker-induced vasodilatation in diabetes is not a consequence of generally reduced retinal vascular reactivity (ClinicalTrials.gov number, NCT00432029).




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T. W. Hein, R. H. Rosa Jr, Z. Yuan, E. Roberts, and L. Kuo
Divergent Roles of Nitric Oxide and Rho Kinase in Vasomotor Regulation of Human Retinal Arterioles
Invest. Ophthalmol. Vis. Sci., March 1, 2010; 51(3): 1583 - 1590.
[Abstract] [Full Text] [PDF]


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