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Originally published In Press as doi:10.1167/iovs.09-3444 on May 14, 2009
 (Investigative Ophthalmology and Visual Science. 2009;50:4091-4096.)
© 2009 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.09-3444
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Relationship of Retinal Vascular Caliber with Retinal Nerve Fiber Layer Thickness: The Singapore Malay Eye Study

Yingfeng Zheng,1,2 Ning Cheung,3 Tin Aung,1,4 Paul Mitchell,5 Mingguang He,2 and Tien Y. Wong1,3,4

1From the Singapore Eye Research Institute, Singapore National Eye Center, Singapore; 2State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; the 3Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; the 4Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; and the 5Centre for Vision Research, University of Sydney, Sydney, Australia.

PURPOSE. To describe the relationship of retinal arteriolar and venular caliber with retinal nerve fiber layer (RNFL) thickness.

METHODS. A population-based, cross-sectional study of Malay persons aged 40 to 80 years residing in Singapore was conducted from 2004 to 2006. Retinal arteriolar and venular calibers were measured with a computer-based technique according to a validated, standardized protocol. RNFL was assessed with retinal tomography.

RESULTS. There were 2706 persons with gradable retinal photographs and HRT images of acceptable quality available for analysis. In linear regression models that adjusted for age, sex, diabetes, body mass index, intraocular pressure, and other factors, each standard deviation decrease in arteriolar and venular caliber was associated with a 5.81- and 8.37-µm decrease, respectively, in mean global RNFL thickness (both P < 0.001). These associations remained similar after persons with glaucoma were excluded. In persons with glaucoma, retinal venular caliber was independently associated with the temporal and temporal-to-inferior region of mean RNFL thickness in multivariate analysis; each SD decrease in retinal venular diameter was associated with an 8.54-µm decrease in the temporal region (P = 0.022), and a 38.32-µm decrease in the temporal-to-inferior region (P = 0.006) of mean RNFL thickness.

CONCLUSIONS. Narrower retinal vessel caliber was associated with reduced RNFL thickness in this Asian population.






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