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Originally published In Press as doi:10.1167/iovs.08-2887 on January 31, 2009
 (Investigative Ophthalmology and Visual Science. 2009;50:4199-4204.)
© 2009 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.08-2887
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The Effects of Optic Disc Drusen on the Latency of the Pattern-Reversal Checkerboard and Multifocal Visual Evoked Potentials

Tomas M. Grippo,1,2 Isaac Ezon,1 Fabio N. Kanadani,1 Boonchai Wangsupadilok,1 Celso Tello,1 Jeffrey M. Liebmann,3,4 Robert Ritch,1,5 and Donald C. Hood6,7

1From the Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York; the 2Department of Medicine, Beth Israel Medical Center, New York, New York; the 3Department of Ophthalmology, New York University, New York, New York; the 4Department of Ophthalmology, Manhattan Eye, Ear, and Throat Hospital, New York, New York; the 5Department of Ophthalmology, New York Medical College, Valhalla, New York; and the 6Departments of Psychology and 7Ophthalmology, Columbia University, New York, New York.

PURPOSE. To determine the effect of optic disc drusen on the latency of the pattern-reversal checkerboard visual evoked potentials (VEPs) and multifocal (mf)VEPs and to better understand the pathophysiology of the condition.

METHODS. Eighteen eyes with optic disc drusen (10 patients) and 38 control eyes (19 subjects) underwent VEP, mfVEP, and visual field testing. Only one eye of each individual, the one with the more affected visual field, was used in the analyses. The VEPs were recorded with a 15' and 60' reversing checkerboard pattern, and the mfVEPs were elicited by a 60-sector dartboard display.

RESULTS. Unlike the VEP results, the mfVEP revealed a significant increase in the average monocular latency of the optic disc drusen group compared with that of the control group. The average mfVEP relative latency for the optic disc drusen group (4.1 ms) was greater than that (0.8 ms) in the control group. For monocular and interocular analyses, the average percentage of points delayed in the drusen group was significantly greater than that in the control group.

CONCLUSIONS. Optic disc drusen produced significant latency delays on the mfVEP test but not on the VEP test, presumably due to the mfVEP’s ability to detect the effects of local changes. The results are consistent with the hypothesis that local mechanical compression by optic disc drusen leads to abnormal retinal ganglion cell activity.






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