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A more recent version of this article appeared on August 1, 2008
 (Investigative Ophthalmology and Visual Science. )
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.07-1320
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Article

Differential Optical Densities of Intraretinal Spaces

Daniel Barthelmes 1*, Florian K Sutter 2, and Mark C. Gillies 3

1 Ophthalmology, University Hospital Bern, Freiburgerstrasse 24, Bern, 3010, Switzerland
2 Ophthalmology, University Hospital Zurich, Zurich, ZH, Switzerland
3 Department of Clinical Ophthalmology, Sydney University, Sydney, New South Wales, Australia

* To whom correspondence should be addressed. E-mail: daniel.barthelmes{at}gmx.ch.


  Abstract

Purpose: To test the hypothesis that hyporeflective spaces in the neuroretina found on optical coherence tomography (OCT) examination have different optical reflectivities according to whether they are associated with exudation or degeneration. Methods: Retrospective analysis of eyes with idiopathic perifoveal telangiectasia (IPT), diabetic macular edema (DME), idiopathic central serous chorioretinopathy (CSC), retinitis pigmentosa (RP), or cone dystrophy (CD), and eyes of healthy controls. OCT scans were performed using a Zeiss Stratus ®OCT (software 4.01). Raw scan data were exported and used to calculate light reflectivity profiles. Reflectivity data were acquired by projecting 3 rectangular boxes, each 50 pixels long and 5 pixels wide, into the intraretinal cystoid spaces, centrally onto unaffected peripheral RPE and onto the prefoveolar vitreous. Light reflectivity values of the retinal pigment epithelium (RPE), the vitreous and intraretinal spaces for the different retinal conditions and controls were compared. Results: Reflectivities of the vitreous and the RPE were similar among the groups. Hyporeflective spaces in eyes with exudation (DME, RP and CSC) had higher reflectivity compared to the mean reflectivity of the vitreous, whereas the cystoid spaces in the maculae of the eyes without exudation (CD and IPT) had a lower reflectivity than the normal vitreous. Conclusion: Analysis of the light reflectivity profiles may be a tool to determine whether the density of hyporeflective spaces in the macula is greater or less than that of the vitreous, and may be a way to differentiate degenerative from exudative macular disease.

Key Words: apoptosis, blood-retinal barrier, cones, macular hole, macular edema, retinal vasculature




eLetters:

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Differential Optical Densities of Intraretinal Spaces
Delia Cabrera Fernandez
IOVS Online, 28 Oct 2008 [Full text]
Author Response: Differential Optical Densities of Intraretinal Spaces
Daniel Barthelmes
IOVS Online, 28 Oct 2008 [Full text]

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