In-vivo three-dimensional imaging of neovascular age related macular degeneration using optical frequency domain imaging at 1050 nm

¹ Lasercenter, Academic Medical Center, Meibergdreef 9, Amsterdam, 1105 AZ, Netherlands; Wellman Center for Photomedicine, Harvard Mass General Hospital, Boston, Massachusetts, United States
² Wellman Center for Photomedicine, Harvard Mass General Hospital, Boston, Massachusetts, United States
³ Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
⁴ Harvard University, Boston, Massachusetts, United States

^* To whom correspondence should be addressed. E-mail: d.m.debruin{at}amc.uva.nl.

	Abstract

Purpose: We undertook a study to assess the application of optical frequency domain imaging (OFDI) at 1050 nm for the detection of choroidal neovascularization (CNV) in age related macular degeneration (AMD) and its response to treatment. Three patients presenting with blurred vision and exudative AMD were imaged before and after treatment with ranibizumab. Methods: Patients were imaged using OFDI, a swept-source based high-speed optical coherence tomography (OCT) system developed at the Wellman Center for Photomedicine. We used a center wavelength of 1050 nm which has previously been demonstrated to provide better imaging of the deeper structures of the retina below the RPE, such as the choroidal vasculature. Three-dimensional data sets were acquired. Results: En-face images were compiled from cross-sectional OFDI data and correlated with color fundus photography (CF) and fluorescein angiograms (FA). Cross-sectional images were co-registered with CF and FA to obtain depth-resolved information about CNV, CNV volume, retinal thickness, subretinal fluid volume and height of neurosensory detachment before and after treatment with ranibizumab. A band of reduced reflectivity below the RPE was identified in all 3 subjects that corresponded to areas of confirmed and suspected occult CNV on FA. Following treatment, this band was reduced in volume in all patients. Conclusions: High-speed 3-D OFDI at 1050 nm is a promising technology for imaging the retina and choroid in neovascular AMD. The developed system at 1050 nm provides good contrast for occult (type 1) CNV, and may have advantages compared with time domain and current state of the art spectral domain OCT systems (SDOCT) at 850 nm.

Key Words: age-related macular degeneration, neovascularization, optical coherence tomography

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