Slow-releasing Paclitaxel in Polytetrafluoroethylene/Polylactide-co-glycolide Laminate Delays Adjustment after Strabismus Surgery in Rabbit Model
Ho Kyung Choung 1,
Su-Eon Jin 2,
Min Joung Lee 3,
Chong-Kook Kim 2,
and
Jeong-Min Hwang 4*
1 Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Boramae Hospital, Seoul, Korea, Republic of
2 Laboratory of Excellency for Drug and Gene Delivery, College of Pharmacy, Seoul National University, Seoul, Korea, Republic of
3 Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea, Republic of
4 Department of Ophthalmology, Seoul National University College of Medicine , Seoul National University Bundang Hospital, Seongnam, Korea, Republic of
* To whom correspondence should be addressed. E-mail: hjm{at}snu.ac.kr.
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Abstract |
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PURPOSE. To determine the usefulness of slow-releasing paclitaxel in polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate for delayed adjustable strabismus surgery.
METHODS. A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After a recession of the superior rectus muscle (SRM), a PTFE/PLGA laminate containing paclitaxel, PTFE alone, or balanced salt solution was applied beneath and over the SRM in the PTFE/PLGA-paclitaxel group (group Paclitaxel), the PTFE group (group PTFE) and the control group, respectively. Delayed adjustment was performed once on each SRM at 3 or 5 weeks postoperatively by a masked observer. Adjustability, adjustment lengths, forces required, and adhesion degrees were evaluated.
RESULTS. In the control group, adjustment was impossible in any eye at 3 or 5 weeks postoperatively. In group PTFE, adjustment was possible in 5 of 8 eyes at 3 weeks postoperatively and in 5 of 10 eyes at 5 weeks postoperatively. In group Paclitaxel, adjustment was possible in 6 of 9 eyes and in 7 of 7 eyes at 3 and 5 weeks postoperatively. On comparing adjustability, a significant difference was observed between group Paclitaxel and the control group at 3 and 5 weeks postoperatively (P = 0.016, P = 0.001, respectively). A significant difference was observed between group Paclitaxel and the control group (P = 0.003) in terms of adhesion between SRMs and sclera at 5 weeks postoperatively.
CONCLUSIONS. Slow-releasing paclitaxel in PTFE/PLGA was found to reduce adhesion and allowed delayed adjustment in most eyes for up to five weeks postoperatively.
Key Words:
strabismus, antiproliferative effects, adjustment
