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A more recent version of this article appeared on March 1, 2010
 (Investigative Ophthalmology and Visual Science. )
© 2009 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.09-3931
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Decreased grey matter concentration in the lateral geniculate nuclei of human amblyopes

Gareth R Barnes,1 Xingfeng Li,2 Benjamin Thompson,3 Krishna Singh,4 Serge O Dumoulin,5 and Robert F Hess6

1Wellcome Dept. Imaging, Institute of Neurology, Queens Square, London, United Kingdom 2Ophthalmology, McGill University, Montreal, Canada 3Optometry, University of Auckland, Auckland, New Zealand 4Psychology, Cardiff University, Cardiff, United Kingdom 5Helmholtz institute, Utrecht University, Utrecht, Netherlands 6Ophthalmology, McGill University, Montreal, Canada

Correspondence: Robert Hess, Email: robert.hess{at}mcgill.ca

Abstract

PURPOSE: In a group of humans with strabismic amblyopia we examined the relationship between the structure and function of different brain regions. We addressed three questions; 1. is the lateral geniculate nucleus (LGN) in humans with amblyopia structurally as well as functionally abnormal? 2. do structural anomalies in the visual cortex correlate with the previously reported cortical functional losses? and 3. is there a link between the functional anomalies in the visual cortex and any structural anomalies in the geniculate?

METHOD: We compared the structure using voxel-based morphometry and the function using functional MRI.

RESULTS: Our results show that the geniculate is structurally abnormal in humans with strabismic amblyopia.

CONCLUSION: These findings add further weight to the role of the LGN in the cortical deficits exhibited by human strabismic amblyopes.

Key Words: amblyopia • LGN • voxel based morphometry • fMRI






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