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A more recent version of this article appeared on October 1, 2008
 (Investigative Ophthalmology and Visual Science. )
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.08-1934
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Article

Heritability of central corneal thickness in Chinese: The Guangzhou Twin Eye Study

Yingfeng Zheng 1, Jian Ge 2, Guofu Huang 1, Jian Zhang 1, Bin Liu 1, Yoon-Mi Hur 3, and Mingguang He 4*

1 Preventive Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
2 Zhongshan Ophthalmic Center, Guangzhou, China
3 Chonnam National University, Gwangju, Korea, Republic of
4 Zhongshan Ophthalmic Center, Zhongshan Ophthalmic Center, Guangzhou, 510060, China

* To whom correspondence should be addressed. E-mail: mingguang_he{at}yahoo.com.


  Abstract

Purpose: To assess the heritability of central corneal thickness in Chinese children using a classical twin study. Methods: Twins aged 8 to 16 years were recruited from Guangzhou Twin Registry. Pachymetry data were obtained using a Pentacam imaging system by the same operator. Zygosity was confirmed by genotyping with 16 polymorphic markers in all same-sex twin pairs. The central corneal thickness (CCT) of the right eyes was chosen as the trait of interest in the analysis. Heritability was assessed by a general sex-limitation model using the Mx program. Results: 449 twin pairs were available for data analyses, including 131 pairs of monozygotic male (MZM), 44 pairs of dizygotic male (DZM), 166 pairs of monozygotic female (MZF), 31 pairs of dizygotic female (DZF), and 77 pairs of opposite sex dizygotic (OSDZ) twins. Twin correlations for CCT were 0.90 for MZM, 0.92 for MZF, 0.56 for DZM, 0.61 for DZF, and 0.44 for OSDZ twins. A sex-limitation model combining additive genetic and unique environmental factors produced the best fit for the data. Heritability estimates for CCT were 0.88 [95% confidence interval (CI): 0.84 to 0.91] in males and 0.91 (95% CI: 0.89 to 0.93) in females. Unique environmental effects explained only 0.12 (95% CI: 0.09 to 0.16) and 0.09 (95% CI: 0.07 to 0.11) of the variance in CCT in males and females, respectively. Conclusion: Additive genetic effects appear to be the major contributor to the variation of CCT in Chinese population. Heritability of CCT was slightly higher in females than in males.

Key Words: Heritability, Corneal thickness, Genetics




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J. A. Landers, A. W. Hewitt, D. P. Dimasi, J. C. Charlesworth, T. Straga, R. A. D. Mills, R. Savarirayan, D. A. Mackey, K. P. Burdon, and J. E. Craig
Heritability of Central Corneal Thickness in Nuclear Families
Invest. Ophthalmol. Vis. Sci., September 1, 2009; 50(9): 4087 - 4090.
[Abstract] [Full Text] [PDF]


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