About the Cover
Cover: Transplanted retinal pigment epithelial (RPE) cells must reattach to a
substrate in order to survive, but the layer of Bruch's membrane available for
transplant attachment has a significant effect on the initial morphology and
subsequent behavior of the cells. Six hours after seeding onto heparinase-treated
basal lamina harvested from a 69-year-old human cadaver eye, numerous
processes extend from the RPE cell to the surface. In contrast, RPE cells remain
round six hours after seeding onto deeper layers of human Bruch's membrane.
See article by Tezel and Del Priore on page 767
of the March 1999 issue. Photographic assistance: Ilene Sugino.
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Copyright © 2006 by the Association for Research in Vision and Ophthalmology
