About the Cover
Cover: The structure of TNF{alpha} with each of the three chains as a different color. The illustration was created based on the coordinates described in: Eck MJ, Sprang SR. The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding. J Biol Chem. 1989;264:17595-17605. The image was drawn using Raster 3D at the Molecules R US website (http://molbio.info.nih.gov/cgi-bin/pdb). This proinflammatory cytokine is central to the allograft rejection process. Rayner et al. describe gene therapy based strategies to block the action of this molecule on page 1568 of this issue.
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Copyright © 2003 by the Association for Research in Vision and Ophthalmology
