Lectures:

King-Wai Yau

Introducing Trevor D. Lamb and Edward N. Pugh, Jr, the 2006 Recipients of the Proctor Medal
2006 47: 5137. [Full Text] [PDF]  

Trevor D. Lamb and Edward N. Pugh, Jr

Phototransduction, Dark Adaptation, and Rhodopsin Regeneration The Proctor Lecture
2006 47: 5138-5152. [Full Text] [PDF] Slide Presentation  

Anatomy and Pathology:

Robert J. Bert, Shelton D. Caruthers, Hernan Jara, Jaroslaw Krejza, Elias R. Melhem, Nancy H. Kolodny, Samuel Patz, and Thomas F. Freddo

Demonstration of an Anterior Diffusional Pathway for Solutes in the Normal Human Eye with High Spatial Resolution Contrast-Enhanced Dynamic MR Imaging
2006 47: 5153-5162. [Abstract] [Full Text] [PDF]  

Mercedes Campos, Juan Amaral, S. Patricia Becerra, and Robert N. Fariss

A Novel Imaging Technique for Experimental Choroidal Neovascularization
2006 47: 5163-5170. [Abstract] [Full Text] [PDF] Supplementary Files  

Christopher Kai-Shun Leung, Shaheeda Mohamed, King Sai Leung, Carol Yim-Lui Cheung, Sylvia Lai-wa Chan, Daphne Ka-yee Cheng, August Ki-cheung Lee, Gloria Yuk-oi Leung, Srinivas Kamalakara Rao, and Dennis Shun Chiu Lam

Retinal Nerve Fiber Layer Measurements in Myopia: An Optical Coherence Tomography Study
2006 47: 5171-5176. [Abstract] [Full Text] [PDF]  

Teresa Sandinha, Maura Farquharson, Ian McKay, and Fiona Roberts

Correlation of Heterogeneity for Chromosome 3 Copy Number with Cell Type in Choroidal Melanoma of Mixed-Cell Type
2006 47: 5177-5180. [Abstract] [Full Text] [PDF]  

Biochemistry and Molecular Biology:

Marijana Samardzija, Andreas Wenzel, Markus Thiersch, Rico Frigg, Charlotte Remé, and Christian Grimm

Caspase-1 Ablation Protects Photoreceptors in a Model of Autosomal Dominant Retinitis Pigmentosa
2006 47: 5181-5190. [Abstract] [Full Text] [PDF]  

Yusuke Takahashi, Gennadiy Moiseyev, Ying Chen, and Jian-xing Ma

The Roles of Three Palmitoylation Sites of RPE65 in Its Membrane Association and Isomerohydrolase Activity
2006 47: 5191-5196. [Abstract] [Full Text] [PDF]  

Lei Zhang, Glynn Baker, Dominika Janus, Carol A. Paddon, Dagmar Fuhrer, and Marian Ludgate

Biological Effects of Thyrotropin Receptor Activation on Human Orbital Preadipocytes
2006 47: 5197-5203. [Abstract] [Full Text] [PDF]  

Futoshi Ishikawa, Hiroshi Ohguro, Ikuyo Ohguro, Hitoshi Yamazaki, Kazuhisa Mamiya, Tomomi Metoki, Tadashi Ito, Yumiko Yokoi, and Mitsuru Nakazawa

Prolonged Rhodopsin Phosphorylation in Light-Induced Retinal Degeneration in Rat Models
2006 47: 5204-5211. [Abstract] [Full Text] [PDF]  

Venu Talla, Chitra Narayanan, Narayanaswamy Srinivasan, and Dorairajan Balasubramanian

Mutation Causing Self-Aggregation in Human C-Crystallin Leading to Congenital Cataract
2006 47: 5212-5217. [Abstract] [Full Text] [PDF]  

Tie Li, Zhenyu Lu, and Luo Lu

Pax6 Regulation in Retinal Cells by CCCTC Binding Factor
2006 47: 5218-5226. [Abstract] [Full Text] [PDF]  

Clinical and Epidemiologic Research:

Julie M. Rosenthal, Jonghyeon Kim, Francisco de Monastario, Darby J. S. Thompson, Richard A. Bone, John T. Landrum, Fabiana F. de Moura, Frederick Khachik, Huiping Chen, Rosemary L. Schleicher, Frederick L. Ferris, III, and Emily Y. Chew

Dose-Ranging Study of Lutein Supplementation in Persons Aged 60 Years or Older
2006 47: 5227-5233. [Abstract] [Full Text] [PDF]  

Frederick Khachik, Fabiana F. de Moura, Emily Y. Chew, Larry W. Douglass, Frederick L. Ferris, III, Jonghyeon Kim, and Darby J. S. Thompson

The Effect of Lutein and Zeaxanthin Supplementation on Metabolites of These Carotenoids in the Serum of Persons Aged 60 or Older
2006 47: 5234-5242. [Abstract] [Full Text] [PDF]  

Cornea:

Vanessa Barbaro, Enzo Di Iorio, Stefano Ferrari, Luigi Bisceglia, Alessandro Ruzza, Michele De Luca, and Graziella Pellegrini

Expression of VSX1 in Human Corneal Keratocytes during Differentiation into Myofibroblasts in Response to Wound Healing
2006 47: 5243-5250. [Abstract] [Full Text] [PDF] Supplementary Figures  

Hsin-Yuan Tan, Yen Sun, Wen Lo, Sung-Jan Lin, Ching-Hsi Hsiao, Yeong-Fong Chen, Samuel Chao-Ming Huang, Wei-Chou Lin, Shiou-Hwa Jee, Hsin-Su Yu, and Chen-Yuan Dong

Multiphoton Fluorescence and Second Harmonic Generation Imaging of the Structural Alterations in Keratoconus Ex Vivo
2006 47: 5251-5259. [Abstract] [Full Text] [PDF]  

Kurt Musselmann, Bradley Kane, Bridgette Alexandrou, and John R. Hassell

Stimulation of Collagen Synthesis by Insulin and Proteoglycan Accumulation by Ascorbate in Bovine Keratocytes In Vitro
2006 47: 5260-5266. [Abstract] [Full Text] [PDF]  

Zheng Wang, Hua Yang, Souvenir D. Tachado, José E. Capó-Aponte, Victor N. Bildin, Henry Koziel, and Peter S. Reinach

Phosphatase-Mediated Crosstalk Control of ERK and p38 MAPK Signaling in Corneal Epithelial Cells
2006 47: 5267-5275. [Abstract] [Full Text] [PDF]  

Romana Kucerova, Jingxing Ou, Diane Lawson, Lucy J. Leiper, and J. Martin Collinson

Cell Surface Glycoconjugate Abnormalities and Corneal Epithelial Wound Healing in the Pax6^+/– Mouse Model of Aniridia-Related Keratopathy
2006 47: 5276-5282. [Abstract] [Full Text] [PDF]  

Almogit Abu, Moshe Frydman, Dina Marek, Eran Pras, Chaim Stolovitch, Ayala Aviram-Goldring, Shlomit Rienstein, Haike Reznik-Wolf, and Elon Pras

Mapping of a Gene Causing Brittle Cornea Syndrome in Tunisian Jews to 16q24
2006 47: 5283-5287. [Abstract] [Full Text] [PDF]  

Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology:

Trevor J. Hine, Guy Wallis, Joanne M. Wood, and Efty P. Stavrou

Reflexive Optokinetic Nystagmus in Younger and Older Observers under Photopic and Mesopic Viewing Conditions
2006 47: 5288-5294. [Abstract] [Full Text] [PDF]  

Fernando Vargas-Martín and Eli Peli

Eye Movements of Patients with Tunnel Vision While Walking
2006 47: 5295-5302. [Abstract] [Full Text] [PDF]  

Piero Barboni, Giacomo Savini, Maria Lucia Valentino, Chiara La Morgia, Costantino Bellusci, Anna Maria De Negri, Federico Sadun, Arturo Carta, Michele Carbonelli, Alfredo A. Sadun, and Valerio Carelli

Leber’s Hereditary Optic Neuropathy with Childhood Onset
2006 47: 5303-5309. [Abstract] [Full Text] [PDF]  

Glaucoma:

Henry Shen-Lih Chen, Robert Ritch, Theodore Krupin, and Wei-Cherng Hsu

Control of Filtering Bleb Structure through Tissue Bioengineering: An Animal Model
2006 47: 5310-5314. [Abstract] [Full Text] [PDF]  

Dan Yi Wang, Bao Jian Fan, John K. H. Chua, Pancy O. S. Tam, Christopher K. S. Leung, Dennis S. C. Lam, and Chi Pui Pang

A Genome-wide Scan Maps a Novel Juvenile-Onset Primary Open-Angle Glaucoma Locus to 15q
2006 47: 5315-5321. [Abstract] [Full Text] [PDF]  

Victoria M. F. Owen, Nicholas G. Strouthidis, David F. Garway-Heath, and David P. Crabb

Measurement Variability in Heidelberg Retina Tomograph Imaging of Neuroretinal Rim Area
2006 47: 5322-5330. [Abstract] [Full Text] [PDF]  

Tomas M. Grippo, Donald C. Hood, Fabio N. Kanadani, Isaac Ezon, Vivienne C. Greenstein, Jeffrey M. Liebmann, and Robert Ritch

A Comparison between Multifocal and Conventional VEP Latency Changes Secondary to Glaucomatous Damage
2006 47: 5331-5336. [Abstract] [Full Text] [PDF]  

Aachal Kotecha, Ahmed Elsheikh, Cynthia R. Roberts, Haogang Zhu, and David F. Garway-Heath

Corneal Thickness- and Age-Related Biomechanical Properties of the Cornea Measured with the Ocular Response Analyzer
2006 47: 5337-5347. [Abstract] [Full Text] [PDF]  

Annemiek Coops, David Barry Henson, Anna J. Kwartz, and Paul Habib Artes

Automated Analysis of Heidelberg Retina Tomograph Optic Disc Images by Glaucoma Probability Score
2006 47: 5348-5355. [Abstract] [Full Text] [PDF]  

Nicholas G. Strouthidis, Veronica Vinciotti, Allan J. Tucker, Stuart K. Gardiner, David P. Crabb, and David F. Garway-Heath

Structure and Function in Glaucoma: The Relationship between a Functional Visual Field Map and an Anatomic Retinal Map
2006 47: 5356-5362. [Abstract] [Full Text] [PDF]  

Xiang-Run Huang, Robert W. Knighton, and Lora N. Cavuoto

Microtubule Contribution to the Reflectance of the Retinal Nerve Fiber Layer
2006 47: 5363-5367. [Abstract] [Full Text] [PDF]  

Tomoyo Funayama, Yukihiko Mashima, Yuichiro Ohtake, Karin Ishikawa, Nobuo Fuse, Noriko Yasuda, Takeo Fukuchi, Akira Murakami, Yoshihiro Hotta, Naoki Shimada, and for The Glaucoma Gene Research Group

SNPs and Interaction Analyses of Noelin 2, Myocilin, and Optineurin Genes in Japanese Patients with Open-Angle Glaucoma
2006 47: 5368-5375. [Abstract] [Full Text] [PDF]  

Immunology and Microbiology:

Sunao Sugita, Hiroshi Keino, Yuri Futagami, Hiroshi Takase, Manabu Mochizuki, Joan Stein-Streilein, and J. Wayne Streilein

B7⁺ Iris Pigment Epithelial Cells Convert T Cells into CTLA-4⁺, B7-Expressing CD8⁺ Regulatory T Cells
2006 47: 5376-5384. [Abstract] [Full Text] [PDF]  

Dale S. Gregerson, Kathleen L. Lew, Scott W. McPherson, Neal D. Heuss, and Deborah A. Ferrington

RPE Cells Resist Bystander Killing by CTLs, but Are Highly Susceptible to Antigen-Dependent CTL Killing
2006 47: 5385-5394. [Abstract] [Full Text] [PDF]  

Lens:

Agnieszka Pladzyk, Aramati B. M. Reddy, Umesh C. S. Yadav, Ravinder Tammali, Kota V. Ramana, and Satish K. Srivastava

Inhibition of Aldose Reductase Prevents Lipopolysaccharide-Induced Inflammatory Response in Human Lens Epithelial Cells
2006 47: 5395-5403. [Abstract] [Full Text] [PDF]  

May-Britt Tessem, Tone F. Bathen, Stefan Löfgren, Oddbjørn Sæther, Vino Mody, Linda Meyer, Xiuqin Dong, Per G. Söderberg, and Anna Midelfart

Biological Response in Various Compartments of the Rat Lens after In Vivo Exposure to UVR-B Analyzed by HR-MAS ¹H NMR Spectroscopy
2006 47: 5404-5411. [Abstract] [Full Text] [PDF]  

Eva Stifter, Stefan Sacu, Arnulf Thaler, and Herbert Weghaupt

Contrast Acuity in Cataracts of Different Morphology and Association to Self-Reported Visual Function
2006 47: 5412-5422. [Abstract] [Full Text] [PDF]  

Physiology and Pharmacology:

Hélène Kergoat, Marie-Ève Hérard, and Marianne Lemay

RGC Sensitivity to Mild Systemic Hypoxia
2006 47: 5423-5427. [Abstract] [Full Text] [PDF]  

Chi-Wing Kong, King-Kit Li, and Chi-Ho To

Chloride Secretion by Porcine Ciliary Epithelium: New Insight into Species Similarities and Differences in Aqueous Humor Formation
2006 47: 5428-5436. [Abstract] [Full Text] [PDF]  

Retina:

Carsten Framme, Helmut G. Sachs, Barbara Flucke, Dirk Theisen-Kunde, and Reginald Birngruber

Evaluation of the New Photosensitizer Tookad (WST09) for Photodynamic Vessel Occlusion of the Choroidal Tissue in Rabbits
2006 47: 5437-5446. [Abstract] [Full Text] [PDF]  

Kegao Liu, James D. Akula, Ronald M. Hansen, Anne Moskowitz, Michael S. Kleinman, and Anne B. Fulton

Development of the Electroretinographic Oscillatory Potentials in Normal and ROP Rats
2006 47: 5447-5452. [Abstract] [Full Text] [PDF]  

Sandra Barral, Peter J. Francis, Dennis W. Schultz, Mitchell B. Schain, Chad Haynes, Jacek Majewski, Jurg Ott, Ted Acott, Richard G. Weleber, and Michael L. Klein

Expanded Genome Scan in Extended Families with Age-Related Macular Degeneration
2006 47: 5453-5459. [Abstract] [Full Text] [PDF]  

Syed Mahmood Shah, Sinan Tatlipinar, Edward Quinlan, Jennifer U. Sung, Homayoun Tabandeh, Quan Dong Nguyen, Ahmed S. Fahmy, Ingrid Zimmer-Galler, R. C. Andrew Symons, Jesse M. Cedarbaum, and Peter A. Campochiaro

Dynamic and Quantitative Analysis of Choroidal Neovascularization by Fluorescein Angiography
2006 47: 5460-5468. [Abstract] [Full Text] [PDF]  

Emi Nakajima, Larry L. David, Cory Bystrom, Thomas R. Shearer, and Mitsuyoshi Azuma

Calpain-Specific Proteolysis in Primate Retina: Contribution of Calpains in Cell Death
2006 47: 5469-5475. [Abstract] [Full Text] [PDF]  

Frederick Khachik, Edra London, Fabiana F. de Moura, Mary Johnson, Scott Steidl, Louis DeTolla, Steven Shipley, Rigoberto Sanchez, Xue-Qing Chen, Jodi Flaws, Gerard Lutty, Scott McLeod, and Bruce Fowler

Chronic Ingestion of (3R,3'R,6'R)-Lutein and (3R,3'R)-Zeaxanthin in the Female Rhesus Macaque
2006 47: 5476-5486. [Abstract] [Full Text] [PDF]  

Michael Pircher, Erich Götzinger, Oliver Findl, Stephan Michels, Wolfgang Geitzenauer, Christina Leydolt, Ursula Schmidt-Erfurth, and Christoph K. Hitzenberger

Human Macula Investigated In Vivo with Polarization-Sensitive Optical Coherence Tomography
2006 47: 5487-5494. [Abstract] [Full Text] [PDF]  

R. Theodore Smith, Jackie K. Chan, Mihai Busuoic, Vasuki Sivagnanavel, Alan C. Bird, and N. Victor Chong

Autofluorescence Characteristics of Early, Atrophic, and High-Risk Fellow Eyes in Age-Related Macular Degeneration
2006 47: 5495-5504. [Abstract] [Full Text] [PDF]  

Md Nawajes A. Mandal, Vidyullatha Vasireddy, G. Bhanuprakash Reddy, XiaoFei Wang, Sayoko E. Moroi, Bikash R. Pattnaik, Bret A. Hughes, John R. Heckenlively, Peter F. Hitchcock, Monica M. Jablonski, and Radha Ayyagari

CTRP5 Is a Membrane-Associated and Secretory Protein in the RPE and Ciliary Body and the S163R Mutation of CTRP5 Impairs Its Secretion
2006 47: 5505-5513. [Abstract] [Full Text] [PDF]  

Md Nawajes A. Mandal, Vidyullatha Vasireddy, Monica M. Jablonski, XiaoFei Wang, John R. Heckenlively, Bret A. Hughes, G. Bhanuprakash Reddy, and Radha Ayyagari

Spatial and Temporal Expression of MFRP and Its Interaction with CTRP5
2006 47: 5514-5521. [Abstract] [Full Text] [PDF]  

Vivek J. Srinivasan, Tony H. Ko, Maciej Wojtkowski, Mariana Carvalho, Allen Clermont, Sven-Erik Bursell, Qin Hui Song, Janis Lem, Jay S. Duker, Joel S. Schuman, and James G. Fujimoto

Noninvasive Volumetric Imaging and Morphometry of the Rodent Retina with High-Speed, Ultrahigh-Resolution Optical Coherence Tomography
2006 47: 5522-5528. [Abstract] [Full Text] [PDF]  

Tomoaki Murakami, Kiyoshi Suzuma, Hitoshi Takagi, Mihori Kita, Hirokazu Ohashi, Daisuke Watanabe, Tomonari Ojima, Masafumi Kurimoto, Tetsushi Kimura, Atsushi Sakamoto, Noriharu Unoki, and Nagahisa Yoshimura

Time-Lapse Imaging of Vitreoretinal Angiogenesis Originating from Both Quiescent and Mature Vessels in a Novel Ex Vivo System
2006 47: 5529-5536. [Abstract] [Full Text] [PDF] Movies  

Retinal Cell Biology:

Sabine Aisenbrey, Minlei Zhang, Daniel Bacher, Jason Yee, William J. Brunken, and Dale D. Hunter

Retinal Pigment Epithelial Cells Synthesize Laminins, Including Laminin 5, and Adhere to Them through 3- and 6-Containing Integrins
2006 47: 5537-5544. [Abstract] [Full Text] [PDF]  

Toshihide Kurihara, Yoko Ozawa, Kei Shinoda, Norihiro Nagai, Makoto Inoue, Yuichi Oike, Kazuo Tsubota, Susumu Ishida, and Hideyuki Okano

Neuroprotective Effects of Angiotensin II Type 1 Receptor (AT1R) Blocker, Telmisartan, via Modulating AT1R and AT2R Signaling in Retinal Inflammation
2006 47: 5545-5552. [Abstract] [Full Text] [PDF]  

Tanyth E. de Gooyer, Kathryn A. Stevenson, Pete Humphries, David A. C. Simpson, Timothy M. Curtis, Tom A. Gardiner, and Alan W. Stitt

Rod Photoreceptor Loss in Rho^–/– Mice Reduces Retinal Hypoxia and Hypoxia-Regulated Gene Expression
2006 47: 5553-5560. [Abstract] [Full Text] [PDF]  

Tanyth E. de Gooyer, Kathryn A. Stevenson, Pete Humphries, David A. C. Simpson, Tom A. Gardiner, and Alan W. Stitt

Retinopathy Is Reduced during Experimental Diabetes in a Mouse Model of Outer Retinal Degeneration
2006 47: 5561-5568. [Abstract] [Full Text] [PDF]  

Saurabh Luthra, Babak Fardin, Joyce Dong, Dieter Hertzog, Sami Kamjoo, Simon Gebremariam, Virit Butani, Raja Narayanan, Jeanie K. Mungcal, Baruch D. Kuppermann, and M. Cristina Kenney

Activation of Caspase-8 and Caspase-12 Pathways by 7-Ketocholesterol in Human Retinal Pigment Epithelial Cells
2006 47: 5569-5575. [Abstract] [Full Text] [PDF]  

Guoliang Jiang, Barbara Mysona, Ying Dun, Jaya P. Gnana-Prakasam, Navjotsin Pabla, Weiguo Li, Zheng Dong, Vadivel Ganapathy, and Sylvia B. Smith

Expression, Subcellular Localization, and Regulation of Sigma Receptor in Retinal Müller Cells
2006 47: 5576-5582. [Abstract] [Full Text] [PDF]  

Lixin Zheng, Robert E. Anderson, Martin-Paul Agbaga, Edmund B. Rucker, III, and Yun-Zheng Le

Loss of BCL-X_L in Rod Photoreceptors: Increased Susceptibility to Bright Light Stress
2006 47: 5583-5589. [Abstract] [Full Text] [PDF]  

Thomas C. Lee, Dena Almeida, Nidia Claros, David H. Abramson, and David Cobrinik

Cell Cycle–Specific and Cell Type–Specific Expression of Rb in the Developing Human Retina
2006 47: 5590-5598. [Abstract] [Full Text] [PDF] Supplementary Material  

Visual Psychophysics and Physiological Optics:

Marc S. Tibber, Antonio Guedes, and Alex J. Shepherd

Orientation Discrimination and Contrast Detection Thresholds in Migraine for Cardinal and Oblique Angles
2006 47: 5599-5604. [Abstract] [Full Text] [PDF]  

Alvin Eisner, Maureen D. Toomey, Lisa J. Incognito, Jean P. O’Malley, and John R. Samples

Contrasting Blue-on-Yellow with White-on-White Visual Fields: Roles of Visual Adaptation for Healthy Peri- or Postmenopausal Women Younger Than 70 Years of Age
2006 47: 5605-5614. [Abstract] [Full Text] [PDF]  

Errata:

ERRATUM
2006 47: 5162. [Full Text] [PDF]  

ERRATUM
2006 47: 5170. [Full Text] [PDF]  

ERRATUM
2006 47: 5180. [Full Text] [PDF]  

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