IOVS
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Online Submission Instructions for Authors
(Last Modified November 16, 2009)

Investigative Ophthalmology & Visual Science (IOVS), published monthly in print and online, is an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purposes are to encourage and assist research, training, publication, and dissemination of knowledge in vision and ophthalmology. Included are original contributions that emphasize clinical and laboratory hypothesis-based research with statistically good results that clearly advance the fields of ophthalmic and vision research. IOVS de-emphasizes purely descriptive research.

Contact Information for IOVS Editorial Office
Address:12300 Twinbrook Parkway
Suite 250
Rockville, MD 20852-1606
Phone:+1.240.221.2920
Fax:+1.240.221.0355
E-mail: iovs{at}arvo.org

Manuscript submission site: http://mc.manuscriptcentral.com/iovs

Contents

Accepted Manuscripts | ARVO Animal Statement | Commercial Relationships Policy
Clinical Trials | Copyright | Declaration of Helsinki | Manuscript Preparation | Manuscript Review
Manuscript Types | Permissions | Publication Costs | Volunteer Editor Program

ARVO/IOVS TERMS AND POLICIES

MANUSCRIPT TYPES

Articles present new data in one or more areas of vision research and are written concisely for a broad rather than a highly specialized audience. To be considered for publication, papers that are merely descriptions of new methods must be exceptional contributions, with implications extending beyond the particular applied area. Summaries of meetings/symposia, case reports, obituaries, and general review articles are not considered.

Lectures are written versions of ARVO awardees' presentations given at each Annual Meeting.

Letters to the Editor will be considered for publication whether their relevance is to material published in IOVS or to issues of general interest to vision scientists. Letters about material published in IOVS may correct errors; provide support or agreement; and offer different points of view, clarification, or additional information. Letters will be reviewed and the author(s) whose article is discussed in a Letter will be given an opportunity to reply. Letters are published online and referenced in the printed journal.

New Developments in Vision Research are solicited short reviews of new research findings or new general methodologies that are of broad interest to the ophthalmic and vision research community.

SCIENTIFIC SECTIONS

ARVO is organized into 13 Scientific Sections. IOVS authors are asked to select and indicate the section code that best suits their research area.

CORRESPONDING AUTHOR RESPONSIBILITIES

  1. Copyright

    1. Prior Publication/Duplicate Submission

      IOVS will not consider any paper or component of a paper that has been published or is under consideration for publication elsewhere. The only exception is when a manuscript submitted to IOVS will also be part of an American Ophthalmological Society thesis. See the IOVS Statement on "Double Publication." Do not submit a new manuscript more than once; this constitutes a double submission and is a violation of the IOVS copyright statement. Distribution on the Internet may be considered previously published material and may compromise the originality of the paper as a submission to IOVS.

    2. Copyright Transfer

      All authors must sign the Copyright Transfer Form. The form(s) may be uploaded to Manuscript Central or e-mailed, faxed, or mailed to the Editorial Office.

    3. Permissions

      If you plan to include figures, photographs, or tables from other publications, obtain written permission from the copyright holder to reprint such items in IOVS, and submit this permission to the Editorial Office.

  2. Other Policies

    1. Declaration of Helsinki

      For research involving human subjects, IOVS requires that authors state in the Methods section of their manuscript that their research adhered to the tenets of the Declaration of Helsinki.

    2. Statement for the Use of Animals in Ophthalmic and Vision Research

      If experimental animals were used in the research, IOVS requires that authors confirm adherence to the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research in the Methods section of their manuscript.

    3. ARVO Commercial Relationships Policy for IOVS

      The ARVO Commercial Relationships Policy ("Policy") for authors, revised as of June 22, 2006, is intended to clarify and simplify the reporting procedures with respect to financial interests in order to promote a better understanding of, and enhanced compliance with, the Policy.

    4. Clinical Trials Registration

      Beginning July 1, 2006, IOVS will no longer consider articles dealing with clinical trials that were not registered before the first subject was enrolled. Trials that began before this date and were not registered must be registered by July 1, 2006. Please include the following information in a cover letter: (1) beginning date of the trial, (2) date of registration, (3) trial registration number, and (4) registration site.

      Registration must be done on a publicly available database. ICMJE-recognized registries as of January 2006 are:
      http://www.actr.org.au (Australia)
      http://www.clinicaltrials.gov (US)
      http://isrctn.org (UK)
      http://www.umin.ac.jp/ctr/index/htm (Japan)
      http://www.trialregister.nl/trialreg/index.asp (Netherlands)

      For the purposes of this policy, a "clinical trial" consists of any study involving a new therapy of any kind, whether medical, surgical, psychological or sociological, in which subjects are concurrently divided into one or more treatment or control groups. Several treatments may be compared simultaneously, or one or more treatment groups may be compared to a simultaneous, untreated control group. Although the division into such groups in most such trials is presently by random assignment, randomization is not a part of the requirement for registration but only the evaluation, in the trial, of concurrent control groups. The size of a clinical trial is not a relevant consideration as to whether it must be registered. This policy applies not only to large, multi-institutional clinical trials sponsored by pharmaceutical companies or other organizations, but also to individual investigators at a single institution who are conducting their own trials. The only consideration is whether the trial is comparing an experimental therapy, or therapies with a simultaneous control group, or groups.

      Click here for more complete guidelines and here for FAQ.

  3. Publication Costs

    1. Manuscript Charges

      Beginning with papers published January 1, 2010, accepted manuscripts will be subject to a $70 per PDF page charge for the first eight (8) pages and $150 per PDF page thereafter. The following guidelines may be used to estimate the length of your manuscript in journal pages:

      3 double-spaced manuscript text pages/12 point type size=1 typeset journal page
      45 references=1 typeset page
      Each figure or table=1/4 to 1/2 typeset page
      Title, authors' names, and abstract=1/2 typeset page

    2. Color Charges

      The cost for color illustrations, $100 per PDF page beginning with papers published January 1, 2010, is borne entirely by the authors. It is recommended that authors submit images in color only if they are prepared to pay the color charge. Authors of accepted manuscripts will be asked to mail or fax a signed Color Charge Approval Statement to the Editorial Office. Please note: if more than one color figure is submitted, it may be necessary to print them on separate pages.

  4. Manuscript Preparation

      Structure: the main manuscript document should be organized as follows:

      a. Title Page
      b. Structured Abstract: 250-word limit
      c. Text
      d. Acknowledgments
      e. References
      f. Figure legends, tables, and figures, if not embedded in text
      Pages should be numbered.

      1. Title Page

        The title page, which must be part of the main manuscript file, should include the title, authors' names and institutions, and other manuscript information such as word count and grant information. The title must contain no more than 150 characters, including punctuation and spaces.

      2. Structured abstract

        A structured abstract of fewer than 250 words is required for articles and should be arranged under the following headings: Purpose, Methods, Results, Conclusions. Define abbreviations at first mention, and do not include references. The abstract must be included as part of the main manuscript file.

      3. Text

        IOVS recommends a 3,500 or fewer word count, excluding title page, legends, and references. The text should be double-spaced.

        In a brief Introduction (don't use any subheadings), provide the research rationale and objectives without extensively reviewing the literature.

        In the Methods section, describe the experimental design, subjects used, and procedures followed. Previously published procedures should be identified by reference only. Provide sufficient detail to enable others to duplicate the research. Use standard chemical or nonproprietary pharmaceutical nomenclature. In parentheses, identify specific sources by brand name, company, city, and state or country.

        If human subjects were involved in the investigation, the Methods section must confirm that: (1) the research followed the tenets of the Declaration of Helsinki; (2) informed consent was obtained from the subjects after explanation of the nature and possible consequences of the study; and (3) where applicable, the research was approved by the institutional human experimentation committee or institutional review board (IRB).

        If experimental animals were used in the investigation, the Methods section must confirm adherence to the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research and, where applicable, approval by the appropriate IRB.

        Present the Results with a minimum of discussion. Cite all tables and figures in numerical order.

        Limit the Discussion to statistically significant data and their limitations. Do not reiterate results.

        Please review your manuscript carefully prior to submission. Authors needing or seeking assistance with English grammar and usage may utilize the IOVS Volunteer Editor Program (see http://www.iovs.org/misc/voleds.shtml).

      4. Acknowledgments

        Acknowledgments should be written in the third person and be limited to colleagues and research assistants. Acknowledgments are not meant to recognize appreciation for personal or manuscript production support. Including dedications to individuals or groups is not permitted by IOVS journal policy.

      5. References

        List references numerically by order of citation in the text, not alphabetically. All references must be cited in the text or tables, shown as superscript numbers. Authors are responsible for the accuracy of references.

        • Unpublished data (including material in preparation or submitted) or personal communications should be listed parenthetically in the text only with year received or recorded.
        • References to journal articles should include (1) author(s) (if there are more than six, write "et al." after the third name), (2) title, (3) journal name (as abbreviated in Index Medicus), (4) year, (5) volume number, and (6) inclusive page numbers.
        • References to books should include (1) author(s), (2) chapter title (if any), (3) editors (if any), (4) title of book, (5) city of publication, (6) publisher, (7) year, and (8) inclusive page numbers.
        • ARVO abstract citations are to appear parenthetically within the text, not as bibliographic references. For ARVO abstracts from 1977 to 2001, citations should include (1) name of first author, (2) "IOVS", (3) year, (4) volume number, (5) "ARVO Abstract", and (6) program number. For ARVO abstracts from 2002 forward, citations should include (1) name of first author, (2) "IOVS", (3) year, (4) volume number, (5) "ARVO E-Abstract", and (6) program number.
        • Reviewers are not required to look up online website references.

          Examples:

          Journals

          Choudhury A, Palkanis VA, Bowers WE. Characterisation and functional activity of dendritic cells from rat choroid. Exp Eye Res. 1994;59:297-304.

          Books

          Stryer L. Biochemistry. 2nd ed. San Francisco, CA: WH Freeman; 1981:559-596.

          Abstracts

          1977-2001: (Otaishat NM, et al. IOVS 1997;38:ARVO Abstract 1417)
          2002- : (Roska BM, et al. IOVS 2002;43:ARVO E-Abstract 1415)

      6. Tables, legends, figures, movies

        1. Tables must be included in the main manuscript file. Each table should have a brief, self-contained title, understandable without reference to the text. Assign a short heading to each table column. Footnotes in tables should use symbols in the following sequence: *, †, ‡, §, ||, and #. Data that can be given in the text in two or three sentences should not be presented in table format.

        2. Legends should sum up the intent and content of the data contained in the figure. Use complete sentences or noun phrases with necessary modifiers, and conclude with a period.

        3. Figures should be cited in the text, in numerical order using Arabic numerals. Figures may be placed within the main manuscript file or uploaded separately. If a figure contains multiple parts, it should be assembled on one page; Figures 1A and 1B should not appear on separate pages. Please label each figure appropriately just beneath the inserted image. For example, labels should read "Fig. 1" or "Figure 1."

          In the event that your manuscript is accepted, the Editorial Office will require you to upload your figures as TIFF or EPS files for the printer. Therefore, while any type of file may be embedded within the manuscript file, it is recommended that graphics be prepared using a program which can save files in a format that can ultimately be saved and submitted as EPS or TIFF. NEW: Color graphics should be saved in RGB (Red, Green, Blue) rather than CMYK (Cyan, Magenta, Yellow, Black). For accepted manuscripts, the minimum resolution requirement for figure files is 300 dpi. Authors of accepted manuscripts can see http://www.iovs.org/misc/accepted.shtml for further details regarding figure requirements for publication.

        4. Movies can be saved as QuickTime files. Since movies can only be viewed online, a movie may be linked to an image (for example, a frame or frames from the movie) that appears as a figure in the manuscript.

    1. File Formats

      Manuscript files will be converted into an unalterable PDF format that will be sent to the reviewers. The main manuscript document must be submitted in one of the following formats:

      • Microsoft Word (.doc): Mac users should manually type in the .doc extension at the end of the file name when they save their document.
      • WordPerfect (.rtf): WordPerfect documents must be saved as Rich Text Format files. Because WordPerfect fonts are not compatible with Adobe, the PDF that Manuscript Central creates may display special characters such as Greek letters and mathematical symbols incorrectly. After you have finished uploading, please be sure to proof the PDF files before clicking on the final submit button. If the special characters do not show up properly, you may have to go back to your original file, change the fonts, and re-upload the file.
      • PDF (.pdf): Should you choose to initially upload a PDF document for peer review, please note that you will need to upload a word processing document, with either a .doc or .rtf extension, upon acceptance.
      • Rich Text Format (.rtf).

      Do not use other word processing systems as they are not supported by Manuscript Central, nor are they all readily available to those involved in the review process.

    2. Style

      Follow guidelines of style, terminology, measurement, and quantitation as set forth in the American Medical Association Manual of Style (9th ed., Baltimore, MD: Williams & Wilkins; 1998).

      • Use initial caps and descriptive clauses for titles and subheadings, avoiding complete sentences or questions.
      • Keep abbreviations and acronyms to a minimum and define them at first mention.
      • Use Système International (SI) measurements (http://physics.nist.gov/cuu/Units/units.html) throughout the paper.
      • Please use basic fonts such as Arial or Times New Roman. Arial is recommended as the font that causes the fewest problems during conversion to PDF.
      • Place equations in their appropriate locations within the text of the manuscript. This will ensure their accurate appearance in the PDF proof.

  5. Web Uploading Instructions

    Submit your manuscript to IOVS online using Manuscript Central at http://mc.manuscriptcentral.com/iovs. Do not submit a manuscript more than once; this constitutes a double submission and is a violation of the IOVS copyright statement. Follow the directions for each screen.

MANUSCRIPT REVIEW AND PUBLICATION

MANUSCRIPT REVIEW

After an initial review of the paper, the Editor-in-Chief assigns it to an Associate Editor (AE). The AE then selects an Editorial Board Member (EBM) who is an expert in the field and who will be responsible for guiding the paper through the review process. The EBM selects several outside reviewers to ensure that two reviewers can be obtained. Once the completed reviews arrive, the EBM critiques them, synthesizing them in a coherent manner for transmission to the corresponding author. At the same time, the EBM recommends a decision to the AE. The AE reviews all material and makes the publication decision, which is then e-mailed to the author. In the case of rejections, the AE forwards their recommendation to the Editor-in-Chief, who makes the final decision. Submissions by nonmembers of ARVO will be given equal consideration. All manuscripts, including invited "New Developments" reviews, ARVO award lectures, and Letters to the Editor, are peer-reviewed.

ACCEPTED MANUSCRIPTS

If your manuscript has been accepted, please see the IOVS website at http://www.iovs.org/misc/accepted.shtml for instructions on how to prepare the final files for publication.

COVER SUBMISSIONS

If you wish to submit an image to be considered for an IOVS cover, please upload a high-resolution image (either EPS or TIFF). Cover submissions may accompany manuscripts or be submitted individually. The submission can be related to a particular manuscript or it can be of a more general scientific nature relevant to IOVS. If the particular image has been published elsewhere or originated as someone else's work, a copyright release or permission must be included. When selecting a picture, please keep in mind the size and shape of the journal cover and remember that the IOVS logo will block part of the image at the top. Remember that enlargement will emphasize any imperfection, so please send the clearest, sharpest image possible.

PERMISSIONS

If you would like to reuse a figure or table from an article that you previously published in IOVS, you do not need written permission. When reprinting the IOVS material, however, please include a full article citation and acknowledge the Association for Research in Vision and Ophthalmology as the copyright holder.

If you would like to use material from an IOVS article for which you were NOT an author, please obtain permission through the Copyright Clearance Center (CCC). There is a fee of $35 per figure or table plus a small CCC service fee. When reprinting the IOVS material, please include a full article citation and acknowledge the Association for Research in Vision and Ophthalmology as the copyright holder. If you have questions or an unusual request, e.g., reuse of material online, please contact Debbie Chin at dchin{at}arvo.org.

All companies, commercial and nonprofit, should contact ARVO directly for permission to reprint articles or parts thereof. Please e-mail your request to Debbie Chin at dchin{at}arvo.org.


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